| http://purl.uniprot.org/citations/10764676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10764676 | http://www.w3.org/2000/01/rdf-schema#comment | "Apolipoproteins of high density lipoprotein (HDL) and especially apolipoprotein (apo)AI and apoAII have been demonstrated as binding directly to the class B type I scavenger receptor (SR-BI), the HDL receptor that mediates selective cholesteryl ester uptake. However, the functional relevance of the binding capacity of each apolipoprotein is still unknown. The human adrenal cell line, NCI-H295R, spontaneously expresses a high level of SR-BI, the major apoAI binding protein in these cells. As previously described for murine SR-BI, free apoAI, palmitoyl-oleoyl-phosphatidylcholine (POPC)-AI, and HDL are good ligands for human SR-BI. In vitro displacement of apoAI by apoAII in HDLs or in Lp AI purified from HDL by immunoaffinity enhances their ability to compete with POPC-AI to bind to SR-BI and also enhances their direct binding capacity. The next step was to determine whether the higher affinity of apoAII for SR-BI correlated with the specific uptake of cholesteryl esters from these HDLs. Free apoAII and, to a lesser extent, free apoAI that were added to the cell medium during uptake experiments inhibited the specific uptake of [(3)H]cholesteryl esters from HDL, indicating that binding sites on cells were the same as cholesteryl ester uptake sites. In direct experiments, the uptake of [(3)H]cholesteryl esters from apoAII-enriched HDL was highly reduced compared with the uptake from native HDL. These results demonstrate that in the human adrenal cell line expressing SR-BI as the major HDL binding protein, efficient apoAII binding has an inhibitory effect on the delivery of cholesteryl esters to cells."xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.atv.20.4.1074"xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/author | "Fruchart J.C."xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/author | "Castro G."xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/author | "Copin C."xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/author | "Briand O."xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/author | "Lestavel S."xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/author | "Pilon A."xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/author | "Majd Z."xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/author | "Clavey V."xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/name | "Arterioscler Thromb Vasc Biol"xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/pages | "1074-1081"xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/title | "Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake."xsd:string |
| http://purl.uniprot.org/citations/10764676 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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