| http://purl.uniprot.org/citations/10764753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10764753 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibitor-1 (I-1) is a specific inhibitor of protein phosphatase-1 (PP1). We assayed the ability of I-1 to inhibit Saccharomyces cerevisiae PP1, Glc7p, in vivo. Glc7p like other PP1 catalytic subunits associates with a variety of noncatalytic subunits, and Glc7p holoenzymes perform distinct physiological roles. Our results show that I-1 inhibits Glc7p holoenzymes that regulate transcription and mitosis, but holoenzymes responsible for meiosis and glycogen metabolism were unaffected. Additionally, we exploited a genetic screen for mutants that were dependent on I-1 to grow. This scheme can identify processes that are negatively regulated by Glc7p-catalyzed dephosphorylation. In this paper I-1-dependent gfa1 mutations were analyzed in detail. GFA1 encodes glutamine-fructose-6-phosphate transaminase. One or more phosphorylated proteins activate GFA1 transcription because the pheromone response and Pkc1p/mitogen-activated protein kinase pathways positively regulate GFA1 transcription. Our findings show that an I-1-sensitive Glc7p holoenzyme reduces GFA1 transcription. Therefore, GFA1 is a member of a growing list of genes that are negatively regulated by Glc7p dephosphorylation."xsd:string |
| http://purl.uniprot.org/citations/10764753 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m000918200"xsd:string |
| http://purl.uniprot.org/citations/10764753 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/10764753 | http://purl.uniprot.org/core/author | "Cannon J.F."xsd:string |
| http://purl.uniprot.org/citations/10764753 | http://purl.uniprot.org/core/author | "Khalil M."xsd:string |
| http://purl.uniprot.org/citations/10764753 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10764753 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10764753 | http://purl.uniprot.org/core/pages | "18070-18078"xsd:string |
| http://purl.uniprot.org/citations/10764753 | http://purl.uniprot.org/core/title | "Glc7p protein phosphatase inhibits expression of glutamine-fructose-6-phosphate transaminase from GFA1."xsd:string |
| http://purl.uniprot.org/citations/10764753 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10764753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10764753 |
| http://purl.uniprot.org/citations/10764753 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10764753 |
| http://purl.uniprot.org/uniprot/#_P14742-mappedCitation-10764753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10764753 |
| http://purl.uniprot.org/uniprot/#_P32598-mappedCitation-10764753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10764753 |
| http://purl.uniprot.org/uniprot/P14742 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10764753 |
| http://purl.uniprot.org/uniprot/P32598 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10764753 |