http://purl.uniprot.org/citations/10766760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10766760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10766760 | http://www.w3.org/2000/01/rdf-schema#comment | "Mcl-1 is a member of the Bcl-2 family that is regulated transcriptionally and post-transcriptionally, with expression of the full-length Mcl-1-encoded gene product resulting in enhanced cell survival. As reported here, the human Mcl-1 gene can also undergo differential splicing, which yields an internally deleted, death-inducing gene product, Mcl-1(s/Delta)(TM). Whereas full-length Mcl-1 derives from three coding exons (instead of the two present in Bcl-2 and other anti-apoptotic members of this family), the Mcl-1(s/Delta)(TM) splice variant results from the joining of the first and third exons with skipping of the central exon. Because of the skipped exon and a shift in the reading frame downstream, the Bcl-2 homology domain (BH3) remains intact, whereas the BH1-, BH2-, and transmembrane-encoding domains do not. Mcl-1(s/Delta)(TM) thus has features similar to BH3 only, pro-apoptotic Bcl-2 family members and, accordingly, was found to promote cell death. In addition to a variety of other types of regulation, the Mcl-1 gene appears ideally designed for the generation of either a Bcl-2-like viability promoting or, as reported here, a BH3 only death-inducing gene product."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m909572199"xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m909572199"xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Zhou P."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Zhou P."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Bingle C.D."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Bingle C.D."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Whyte M.K.B."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Whyte M.K.B."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Singleton V."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Singleton V."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Craig R.W."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Craig R.W."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Swales B.M."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/author | "Swales B.M."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/pages | "22136-22146"xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/pages | "22136-22146"xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/title | "Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death."xsd:string |
http://purl.uniprot.org/citations/10766760 | http://purl.uniprot.org/core/title | "Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death."xsd:string |