| http://purl.uniprot.org/citations/10767560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10767560 | http://www.w3.org/2000/01/rdf-schema#comment | "The RNA-dependent protein kinase (PKR) is implicated in the antiviral and antiproliferative actions of interferon (IFN). As an extension of our structural characterization of the exon-intron organization of the mouse Pkr gene, we now have isolated and characterized the mouse Pkr promoter region required for IFN-inducible transcription. Transient transfection analyses, using reporter constructs possessing various 5'-flanking fragments of the Pkr gene, led to the identification of a functional IFN-inducible promoter. A single IFN-stimulated response element (ISRE) was present in a minimal 44-nt TATA-less promoter identified by deletion analysis; the 13-nt ISRE differed from previously described ISRE elements in that the 3'-nt was a purine instead of a pyrimidine. The sequence immediately upstream of the ISRE possessed the 15-nt KCS element that was exactly conserved in sequence and position between the mouse and human Pkr promoters. A single gamma IFN-activated sequence (GAS)-like element and multiple recognition sites for factors including NF-kappaB and NF-IL6 involved in responses to various cytokine and hormone signals in inflammatory responses were also present in the 5'-flanking region. Northern blot analysis showed efficient IFN-alpha induced accumulation of 2.4kb, 4.5kb and approx. 6kb Pkr transcripts, but neither IFN-gamma nor IL-6 induced detectable Pkr mRNA accumulation in L cells."xsd:string |
| http://purl.uniprot.org/citations/10767560 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(00)00080-9"xsd:string |
| http://purl.uniprot.org/citations/10767560 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/10767560 | http://purl.uniprot.org/core/author | "Samuel C.E."xsd:string |
| http://purl.uniprot.org/citations/10767560 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10767560 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/10767560 | http://purl.uniprot.org/core/pages | "373-382"xsd:string |
| http://purl.uniprot.org/citations/10767560 | http://purl.uniprot.org/core/title | "Mouse interferon-inducible RNA-dependent protein kinase Pkr gene: cloning and sequence of the 5'-flanking region and functional identification of the minimal inducible promoter."xsd:string |
| http://purl.uniprot.org/citations/10767560 | http://purl.uniprot.org/core/volume | "246"xsd:string |
| http://purl.uniprot.org/citations/10767560 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10767560 |
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| http://purl.uniprot.org/uniprot/#_Q03963-mappedCitation-10767560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10767560 |
| http://purl.uniprot.org/uniprot/#_Q78E06-mappedCitation-10767560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10767560 |
| http://purl.uniprot.org/uniprot/#_Q91YN2-mappedCitation-10767560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10767560 |
| http://purl.uniprot.org/uniprot/Q78E06 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10767560 |
| http://purl.uniprot.org/uniprot/Q03963 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10767560 |
| http://purl.uniprot.org/uniprot/Q91YN2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10767560 |