| http://purl.uniprot.org/citations/10775035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10775035 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-Raf-1 kinase is a downstream effector of Ras signaling. Both proteins are highly oncogenic when they are mutationally activated, but only the Ras GTPase is frequently mutated in naturally occurring tumors. Although the c-Raf-1 protein was found to be amplified in different lung cancer cell lines, overexpression of the wild-type c-Raf-1 protein was shown to be insufficient to transform cultured cells. Here we have addressed the question of whether overexpression of the wild-type c-Raf-1 kinase can induce lung cancer in mice. We show that lung-targeted expression of oncogenically activated or wild-type c-Raf-1 proteins induces morphologically indistinguishable lung adenomas in transgenic mice. Compared with mice transgenic for the activated c-Raf-1-BxB, tumor development is delayed and occurs at a lower incidence in wild-type c-Raf-1 transgenic mice. Our studies show that the c-Raf-1 expression level is a critical parameter in tumor development and should be analyzed in more detail to evaluate its potential in the induction of cancer."xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/author | "Rapp U.R."xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/author | "Fedorov L.M."xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/author | "Papadopoulos T."xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/author | "Walter A.O."xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/author | "Kerkhoff E."xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/author | "Siefken R."xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/name | "Cell Growth Differ"xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/pages | "185-190"xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/title | "Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein."xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/10775035 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10775035 |
| http://purl.uniprot.org/citations/10775035 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10775035 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV36-mappedCitation-10775035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10775035 |
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