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| http://purl.uniprot.org/citations/10781109 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the potential of double-stranded RNA interference (RNAi) with gene activity in Arabidopsis thaliana. To construct transformation vectors that produce RNAs capable of duplex formation, gene-specific sequences in the sense and antisense orientations were linked and placed under the control of a strong viral promoter. When introduced into the genome of A. thaliana by Agrobacterium-mediated transformation, double-stranded RNA-expressing constructs corresponding to four genes, AGAMOUS (AG), CLAVATA3, APETALA1, and PERIANTHIA, caused specific and heritable genetic interference. The severity of phenotypes varied between transgenic lines. In situ hybridization revealed a correlation between a declining AG mRNA accumulation and increasingly severe phenotypes in AG (RNAi) mutants, suggesting that endogenous mRNA is the target of double-stranded RNA-mediated genetic interference. The ability to generate stably heritable RNAi and the resultant specific phenotypes allows us to selectively reduce gene function in A. thaliana."xsd:string |
| http://purl.uniprot.org/citations/10781109 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.060034297"xsd:string |
| http://purl.uniprot.org/citations/10781109 | http://purl.uniprot.org/core/author | "Meyerowitz E.M."xsd:string |
| http://purl.uniprot.org/citations/10781109 | http://purl.uniprot.org/core/author | "Chuang C.F."xsd:string |
| http://purl.uniprot.org/citations/10781109 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10781109 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/10781109 | http://purl.uniprot.org/core/pages | "4985-4990"xsd:string |
| http://purl.uniprot.org/citations/10781109 | http://purl.uniprot.org/core/title | "Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana."xsd:string |
| http://purl.uniprot.org/citations/10781109 | http://purl.uniprot.org/core/volume | "97"xsd:string |
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