| http://purl.uniprot.org/citations/10793136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10793136 | http://www.w3.org/2000/01/rdf-schema#comment | "Fertilization occurs after the completion of the sperm acrosome reaction, a secretory event that is triggered during gamete adhesion. ZP3, an egg zona pellucida glycoprotein, produces a sustained increase of the internal Ca(2+) concentration in mouse sperm, leading to acrosome reactions. Here we show that the sustained Ca(2+) concentration increase is due to the persistent activation of a Ca(2+) influx mechanism during the late stages of ZP3 signal transduction. These cells also possess a Ca(2+) store depletion-activated Ca(2+) entry pathway that is open after treatment with thapsigargin. Thapsigargin and ZP3 activate the same Ca(2+) permeation mechanism, as demonstrated by fluorescence quenching experiments and by channel antagonists. These studies show that ZP3 generates a sustained Ca(2+) influx through a store depletion-operated pathway and that this drives the exocytotic acrosome reaction."xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.11.5.1571"xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://purl.uniprot.org/core/author | "Arnoult C."xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://purl.uniprot.org/core/author | "Darszon A."xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://purl.uniprot.org/core/author | "Florman H.M."xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://purl.uniprot.org/core/author | "Steinhardt R.A."xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://purl.uniprot.org/core/author | "O'Toole C.M."xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10793136 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://purl.uniprot.org/core/pages | "1571-1584"xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://purl.uniprot.org/core/title | "Ca(2+) entry through store-operated channels in mouse sperm is initiated by egg ZP3 and drives the acrosome reaction."xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/10793136 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10793136 |
| http://purl.uniprot.org/citations/10793136 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10793136 |
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