| http://purl.uniprot.org/citations/10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10797013 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine why proteasome inhibitors prevent thymocyte death, we examined whether proteasomes degrade anti-apoptotic molecules in cells induced to undergo apoptosis. The c-IAP1 and XIAP inhibitors of apoptosis were selectively lost in glucocorticoid- or etoposide-treated thymocytes in a proteasome-dependent manner before death. IAPs catalyzed their own ubiquitination in vitro, an activity requiring the RING domain. Overexpressed wild-type c-IAP1, but not a RING domain mutant, was spontaneously ubiquitinated and degraded, and stably expressed XIAP lacking the RING domain was relatively resistant to apoptosis-induced degradation and, correspondingly, more effective at preventing apoptosis than wild-type XIAP. Autoubiquitination and degradation of IAPs may be a key event in the apoptotic program."xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.288.5467.874"xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://purl.uniprot.org/core/author | "Weissman A.M."xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://purl.uniprot.org/core/author | "Fang S."xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://purl.uniprot.org/core/author | "Jensen J.P."xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://purl.uniprot.org/core/author | "Ashwell J.D."xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10797013 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://purl.uniprot.org/core/pages | "874-877"xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://purl.uniprot.org/core/title | "Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli."xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/10797013 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10797013 |
| http://purl.uniprot.org/citations/10797013 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10797013 |
| http://purl.uniprot.org/uniprot/#_Q15008-mappedCitation-10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10797013 |
| http://purl.uniprot.org/uniprot/#_A5LHX3-mappedCitation-10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10797013 |
| http://purl.uniprot.org/uniprot/#_O14788-mappedCitation-10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10797013 |
| http://purl.uniprot.org/uniprot/#_O43242-mappedCitation-10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10797013 |
| http://purl.uniprot.org/uniprot/#_P40306-mappedCitation-10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10797013 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10797013 |
| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10797013 |
| http://purl.uniprot.org/uniprot/#_Q13200-mappedCitation-10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10797013 |
| http://purl.uniprot.org/uniprot/#_Q14997-mappedCitation-10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10797013 |
| http://purl.uniprot.org/uniprot/#_O00231-mappedCitation-10797013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10797013 |