| http://purl.uniprot.org/citations/10798398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10798398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10798398 | http://www.w3.org/2000/01/rdf-schema#comment | "Acidosis is associated with inflammation and ischemia and activates cation channels in sensory neurons. Inflammation also induces expression of FMRFamidelike neuropeptides, which modulate pain. We found that neuropeptide FF (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide) and FMRFamide (Phe-Met-Arg-Phe amide) generated no current on their own but potentiated H+-gated currents from cultured sensory neurons and heterologously expressed ASIC and DRASIC channels. The neuropeptides slowed inactivation and induced sustained currents during acidification. The effects were specific; different channels showed distinct responses to the various peptides. These results suggest that acid-sensing ion channels may integrate multiple extracellular signals to modify sensory perception."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(00)81144-7"xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(00)81144-7"xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Cheng C."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Cheng C."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Welsh M.J."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Welsh M.J."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Askwith C.C."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Askwith C.C."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Benson C."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Benson C."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Ikuma M."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Ikuma M."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Price M.P."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/author | "Price M.P."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/pages | "133-141"xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/pages | "133-141"xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/title | "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels."xsd:string |
| http://purl.uniprot.org/citations/10798398 | http://purl.uniprot.org/core/title | "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels."xsd:string |