| http://purl.uniprot.org/citations/10799894 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10799894 | http://www.w3.org/2000/01/rdf-schema#comment | "CTLA-4-mediated inhibition of T cell activation may be accomplished by competition for ligands and/or by signals mediated through the intracellular domain. Studies have implicated Tyr201 in the cytoplasmic domain of CTLA-4 in regulating CTLA-4 signal transduction and intracellular trafficking. To investigate the mechanism of CTLA-4 function in vivo, transgenes encoding wild-type CTLA-4 (FL), a mutant lacking the cytoplasmic domain of CTLA-4 (DeltaCTLA-4 tail), or a CTLA-4 Tyr201 mutant (Y201V) were introduced into CTLA-4-deficient mice. CTLA-4-/-mice display an autoimmune lymphoproliferative disorder resulting in tissue destruction and early death. When either the FL or the Y201V transgene was bred into CTLA-4-/-animals, a complete rescue from lymphoproliferation and autoimmunity was observed. In contrast, CTLA-4-/-mice expressing the DeltaCTLA-4 tail transgene were long lived with no evidence of multiorgan lymphocytic infiltration, but exhibited lymphadenopathy and accumulated large numbers of activated T cells. Furthermore, these animals displayed a Th2-biased phenotype which conferred susceptibility to Leishmania infection. These results indicate that the inhibitory effect of CTLA-4 is mediated in part through the ability of the extracellular domain to compete for ligands. The cytoplasmic domain of CTLA-4, however, is required for complete inhibitory function of the receptor and for regulation of Th cell differentiation in vivo."xsd:string |
| http://purl.uniprot.org/citations/10799894 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.164.10.5319"xsd:string |
| http://purl.uniprot.org/citations/10799894 | http://purl.uniprot.org/core/author | "Thompson C.B."xsd:string |
| http://purl.uniprot.org/citations/10799894 | http://purl.uniprot.org/core/author | "Chuang E."xsd:string |
| http://purl.uniprot.org/citations/10799894 | http://purl.uniprot.org/core/author | "Mullen A.C."xsd:string |
| http://purl.uniprot.org/citations/10799894 | http://purl.uniprot.org/core/author | "Reiner S.L."xsd:string |
| http://purl.uniprot.org/citations/10799894 | http://purl.uniprot.org/core/author | "Masteller E.L."xsd:string |
| http://purl.uniprot.org/citations/10799894 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10799894 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10799894 | http://purl.uniprot.org/core/pages | "5319-5327"xsd:string |
| http://purl.uniprot.org/citations/10799894 | http://purl.uniprot.org/core/title | "Structural analysis of CTLA-4 function in vivo."xsd:string |
| http://purl.uniprot.org/citations/10799894 | http://purl.uniprot.org/core/volume | "164"xsd:string |
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