| http://purl.uniprot.org/citations/10801787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10801787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10801787 | http://www.w3.org/2000/01/rdf-schema#comment | "Branching morphogenesis is a central event during the development of kidneys, lungs, and other organs. We previously generated a monoclonal antibody, 3D2-E9, that inhibited branching morphogenesis and caused widespread apoptosis. We now report the purification of its antigen and cloning of its full-length cDNA. Its cDNA encodes an integral membrane protein that contains four cadherin-like ectodomains and a thrice tandemly repeated region enriched in threonine, serine, and proline, similar to those of mucins. We thus term this protein mu-protocadherin, reflecting the hybrid nature of its extracellular region. mu-Protocadherin is expressed in two forms that are developmentally regulated, with the shorter isoform lacking the mucin-like repeats. Expression of the long isoform in heterologous cells results in adhesion of the expressing cells, suggesting that it is a new cell adhesion molecule. mu-Protocadherin contains both N and O glycosylations. It is expressed at lateral and basal surfaces of epithelia during kidney and lung development and is located in coated pits. Colocalization of mu-protocadherin with beta-catenin was noted primarily at the junction of the lateral and basal membrane. The cytoplasmic domain contains four proline-rich regions, similar to SH3 binding regions. Thus, it is likely that adhesive interactions mediated by mu-protocadherin induce signaling events that regulate branching morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m000234200"xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m000234200"xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/author | "Goldberg M."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/author | "Goldberg M."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/author | "Al-Awqati Q."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/author | "Al-Awqati Q."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/author | "Peshkovsky C."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/author | "Peshkovsky C."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/author | "Shifteh A."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/author | "Shifteh A."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/pages | "24622-24629"xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/pages | "24622-24629"xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/title | "mu-protocadherin, a novel developmentally regulated protocadherin with mucin-like domains."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/title | "mu-protocadherin, a novel developmentally regulated protocadherin with mucin-like domains."xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10801787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10801787 |
| http://purl.uniprot.org/citations/10801787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10801787 |