| http://purl.uniprot.org/citations/10801873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10801873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10801873 | http://www.w3.org/2000/01/rdf-schema#comment | "The Raf-1 kinase plays a key role in relaying proliferation signals elicited by mitogens or oncogenes. Raf-1 is regulated by complex and incompletely understood mechanisms including phosphorylation. A number of studies have indicated that phosphorylation of serines 259 and 621 can inhibit the Raf-1 kinase. We show that both serines are hypophosphorylated during early mitogenic stimulation and that hypophosphorylation correlates with peak Raf-1 activation. Concentrations of okadaic acid that selectively inhibit protein phosphatase 2A (PP2A) induce phosphorylation of these residues and prevent maximal activation of the Raf-1 kinase. This effect is mediated via phosphorylation of serine 259. The PP2A core heterodimer forms complexes with Raf-1 in vivo and in vitro. These data identify PP2A as a positive regulator of Raf-1 activation and are the first indication that PP2A may support the activation of an associated kinase."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m003259200"xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m003259200"xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Abraham D."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Abraham D."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Baccarini M."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Baccarini M."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Dilworth S.M."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Dilworth S.M."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Hemmings B.A."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Hemmings B.A."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Kolch W."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Kolch W."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Kubicek M."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Kubicek M."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Mischak H."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Mischak H."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Pacher M."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Pacher M."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Podar K."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Podar K."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Welzel N."xsd:string |
| http://purl.uniprot.org/citations/10801873 | http://purl.uniprot.org/core/author | "Welzel N."xsd:string |