| http://purl.uniprot.org/citations/10805721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10805721 | http://www.w3.org/2000/01/rdf-schema#comment | "Absence of Ku80 results in increased sensitivity to ionizing radiation, defective lymphocyte development, early onset of an age-related phenotype, and premature replicative senescence. Here we investigate the role of p53 on the phenotype of ku80-mutant mice and cells. Reducing levels of p53 increased the cancer incidence for ku80(-/-) mice. About 20% of ku80(-/-) p53(+/-) mice developed a broad spectrum of cancer by 40 weeks and all ku80(-/-) p53(-/-) mice developed pro-B-cell lymphoma by 16 weeks. Reducing levels of p53 rescued populations of ku80(-/-) cells from replicative senescence by enabling spontaneous immortalization. The double-mutant cells are impaired for the G(1)/S checkpoint due to the p53 mutation and are hypersensitive to gamma-radiation and reactive oxygen species due to the Ku80 mutation. These data show that replicative senescence is caused by a p53-dependent cell cycle response to damaged DNA in ku80(-/-) cells and that p53 is essential for preventing very early onset of pro-B-cell lymphoma in ku80(-/-) mice."xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.11.3772-3780.2000"xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/author | "Vogel H."xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/author | "Platt K.A."xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/author | "Sands A.T."xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/author | "Lim D.S."xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/author | "Hasty P."xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/author | "Willerford D.M."xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/pages | "3772-3780"xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/title | "Analysis of ku80-mutant mice and cells with deficient levels of p53."xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10805721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10805721 |
| http://purl.uniprot.org/citations/10805721 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10805721 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-10805721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10805721 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-10805721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10805721 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-10805721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10805721 |
| http://purl.uniprot.org/uniprot/#_P02340-mappedCitation-10805721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10805721 |
| http://purl.uniprot.org/uniprot/#_Q3UGQ1-mappedCitation-10805721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10805721 |
| http://purl.uniprot.org/uniprot/#_O70366-mappedCitation-10805721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10805721 |
| http://purl.uniprot.org/uniprot/#_Q80ZA1-mappedCitation-10805721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10805721 |
| http://purl.uniprot.org/uniprot/#_P27641-mappedCitation-10805721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10805721 |
| http://purl.uniprot.org/uniprot/#_Q64451-mappedCitation-10805721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10805721 |