| http://purl.uniprot.org/citations/10809666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10809666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10809666 | http://www.w3.org/2000/01/rdf-schema#comment | "The Caenorhabditis elegans meiotic spindle is morphologically distinct from the first mitotic spindle, yet both structures form in the same cytoplasm approximately 20 minutes apart. The mei-1 and mei-2 genes of C. elegans are required for the establishment of the oocyte meiotic spindle but are not required for mitotic spindle function. mei-1 encodes an AAA ATPase family member with similarity to the p60 catalytic subunit of the heterodimeric sea urchin microtubule-severing protein, katanin. We report that mei-2 encodes a 280-amino acid protein containing a region similar to the p80-targeting subunit of katanin. MEI-1 and MEI-2 antibodies decorate the polar ends of meiotic spindle microtubules and meiotic chromatin. We find that the subcellular location of MEI-2 depends on wild-type mei-1 activity and vice versa. These experiments, combined with MEI-1 and MEI-2's similarity to p60 and p80 katanin, suggest that the C. elegans proteins function as a complex. In support of this idea, MEI-1 and MEI-2 physically associate in HeLa cells. Furthermore, co-expression of MEI-1 and MEI-2 in HeLa cells results in the disassembly of microtubules. These data lead us to conclude that MEI-1/MEI-2 microtubule-severing activity is required for meiotic spindle organization in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/author | "Srayko M."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/author | "Srayko M."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/author | "Buster D.W."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/author | "Buster D.W."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/author | "Mains P.E."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/author | "Mains P.E."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/author | "McNally F.J."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/author | "McNally F.J."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/author | "Bazirgan O.A."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/author | "Bazirgan O.A."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/pages | "1072-1084"xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/pages | "1072-1084"xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/title | "MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/title | "MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis."xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/10809666 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10809666 |
| http://purl.uniprot.org/citations/10809666 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10809666 |