| http://purl.uniprot.org/citations/10810289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10810289 | http://www.w3.org/2000/01/rdf-schema#comment | "Many tumours secrete IGF-II in incompletely processed precursor forms. The ability of these pro-IGF-II forms to complex with the six IGF binding proteins (IGFBPs) is poorly understood. In this study, pro-IGF-II has been extracted from the serum and tumour tissue of two patients with non-islet cell tumour hypoglycaemia. These samples were used to study binary complex formation with IGFBPs-1 to -6 using competitive IGF-II binding assays and ternary complex formation with IGFBP-3 and IGFBP-5. In each case, IGFBPs-1 to -6 showed little difference in their ability to form binary complexes with recombinant IGF-II or tumour-derived pro-IGF-II forms, when the preparations were standardised according to IGF-II immunoreactivity. As previously described, ternary complex formation by acid-labile subunit (ALS) with IGFBP-3 and pro-IGF-II was greatly decreased compared with complex formation with mature IGF-II. In contrast, ALS bound similarly to IGFBP-5 in the presence of pro-IGF-II and mature IGF-II. These studies suggest that pro-IGF-II preferentially forms binary complexes with IGFBPs, and ternary complexes with IGFBP-5, rather than ternary complexes with IGFBP-3 as seen predominantly in normal serum. This may increase the tissue availability of serum pro-IGF-II, allowing its insulin-like potential to be realised."xsd:string |
| http://purl.uniprot.org/citations/10810289 | http://purl.org/dc/terms/identifier | "doi:10.1677/joe.0.1650253"xsd:string |
| http://purl.uniprot.org/citations/10810289 | http://purl.uniprot.org/core/author | "Baxter R.C."xsd:string |
| http://purl.uniprot.org/citations/10810289 | http://purl.uniprot.org/core/author | "Meka S."xsd:string |
| http://purl.uniprot.org/citations/10810289 | http://purl.uniprot.org/core/author | "Bond J.J."xsd:string |
| http://purl.uniprot.org/citations/10810289 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10810289 | http://purl.uniprot.org/core/name | "J Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/10810289 | http://purl.uniprot.org/core/pages | "253-260"xsd:string |
| http://purl.uniprot.org/citations/10810289 | http://purl.uniprot.org/core/title | "Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6."xsd:string |
| http://purl.uniprot.org/citations/10810289 | http://purl.uniprot.org/core/volume | "165"xsd:string |
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