| http://purl.uniprot.org/citations/10811620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10811620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10811620 | http://www.w3.org/2000/01/rdf-schema#comment | "Pax5 (BSAP) functions as both a transcriptional activator and repressor during midbrain patterning, B-cell development and lymphomagenesis. Here we demonstrate that Pax5 exerts its repression function by recruiting members of the Groucho corepressor family. In a yeast two-hybrid screen, the groucho-related gene product Grg4 was identified as a Pax5 partner protein. Both proteins interact cooperatively via two separate domains: the N-terminal Q and central SP regions of Grg4, and the octapeptide motif and C-terminal transactivation domain of Pax5. The phosphorylation state of Grg4 is altered in vivo upon Pax5 binding. Moreover, Grg4 efficiently represses the transcriptional activity of Pax5 in an octapeptide-dependent manner. Similar protein interactions resulting in transcriptional repression were also observed between distantly related members of both the Pax2/5/8 and Groucho protein families. In agreement with this evolutionary conservation, the octapeptide motif of Pax proteins functions as a Groucho-dependent repression domain in Drosophila embryos. These data indicate that Pax proteins can be converted from transcriptional activators to repressors through interaction with corepressors of the Groucho protein family."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.10.2292"xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.10.2292"xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/author | "Jimenez G."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/author | "Jimenez G."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/author | "Eberhard D."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/author | "Eberhard D."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/author | "Heavey B."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/author | "Heavey B."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/pages | "2292-2303"xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/pages | "2292-2303"xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/title | "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/title | "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family."xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10811620 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10811620 |
| http://purl.uniprot.org/citations/10811620 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10811620 |