| http://purl.uniprot.org/citations/10811811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10811811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10811811 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a rice gene encoding a DNA-binding protein that specifically recognizes the telomeric repeat sequence TTTAGGG found in plants. This gene, which we refer to as RTBP1 (rice telomere-binding protein 1), encodes a polypeptide with a predicted molecular mass of 70 kDa. RTBP1 is ubiquitously expressed in various organs and binds DNA with two or more duplex TTTAGGG repeats. The predicted protein sequence includes a single domain at the C terminus with extensive homology to Myb-like DNA binding motif. The Myb-like domain of RTBP1 is very closely related to that of other telomere-binding proteins, including TRF1, TRF2, Taz1p, and Tbf1p, indicating that DNA-binding domains of telomere-binding proteins are well conserved among evolutionarily distant species. To obtain precise information on the sequence of the DNA binding site recognized by RTBP1, we analyzed the sequence-specific binding properties of the isolated Myb-like domain of RTBP1. The isolated Myb-like domain was capable of sequence-specific DNA binding as a homodimer. Gel retardation analysis with a series of mutated telomere probes revealed that the internal GGGTTT sequence in the two-telomere repeats is critical for binding of Myb-like domain of RTBP1, which is consistent with the model of the TRF1.DNA complex showing that base-specific contacts are made within the sequence GGGTTA. To the best of our knowledge, RTBP1 is the first cloned gene in which the product is able to bind double-stranded telomeric DNA in plants. Because the Myb-like domain appears to be a significant motif for a large class of proteins that bind the duplex telomeric DNA, RTBP1 may play important roles in plant telomere function in vivo."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m003250200"xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m003250200"xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Kim S.E."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Kim S.E."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Ko J.H."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Ko J.H."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Cho M.H."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Cho M.H."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Chung I.K."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Chung I.K."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Yu E.Y."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/author | "Yu E.Y."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/pages | "24208-24214"xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/pages | "24208-24214"xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/title | "Sequence-specific DNA recognition by the Myb-like domain of plant telomeric protein RTBP1."xsd:string |
| http://purl.uniprot.org/citations/10811811 | http://purl.uniprot.org/core/title | "Sequence-specific DNA recognition by the Myb-like domain of plant telomeric protein RTBP1."xsd:string |