| http://purl.uniprot.org/citations/10817758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10817758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10817758 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulated mRNA turnover is a highly important process, but its mechanism is poorly understood. Using interleukin-2 (IL-2) mRNA as a model, we described a role for the JNK-signaling pathway in stabilization of IL-2 mRNA during T-cell activation, acting via a JNK response element (JRE) in the 5' untranslated region (UTR). We have now identified two major RNA-binding proteins, nucleolin and YB-1, that specifically bind to the JRE. Binding of both proteins is required for IL-2 mRNA stabilization induced by T-cell activation signals and for JNK-induced stabilization in a cell-free system that duplicates essential features of regulated mRNA decay. Nucleolin and YB-1 are required for formation of an IL-2 mRNP complex that responds to specific mRNA stabilizing signals."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Andersen J.S."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Andersen J.S."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Chen C.-Y."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Chen C.-Y."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Gherzi R."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Gherzi R."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Gaietta G."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Gaietta G."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Juerchott K."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Juerchott K."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Royer H.-D."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/author | "Royer H.-D."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/pages | "1236-1248"xsd:string |
| http://purl.uniprot.org/citations/10817758 | http://purl.uniprot.org/core/pages | "1236-1248"xsd:string |