| http://purl.uniprot.org/citations/10828887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10828887 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the cdc25 family are protein phosphatases that play pivotal roles in cell cycle progression. Cdc25A has been shown to be a critical regulator of the G1/S transition of mammalian cells and to be a myc-target gene with oncongenic properties. We investigated the regulation of cdc25A during terminal differentiation using myeloblastic leukemia M1 cells, that can be induced to undergo differentiation into macrophages by interleukin-6 (IL-6) treatment. In this report it is shown that cdc25A protein is degraded by the ubiquitin-proteasome machinery in both terminally differentiating and cycling cells. Cdc25A was found to have two major peaks of accumulation during cell cycle progression, one in G1 and the other in S/G2. Evidence was obtained that degradation of cdc25A by the ubiquitin-proteasome machinery in terminally differentiating myeloid cells is accelerated compared to cycling cells. Moreover, deregulated expression of c-myc in M1 cells, which had been previously shown to block terminal differentiation, was also found to block IL-6 induced degradation of cdc25A."xsd:string |
| http://purl.uniprot.org/citations/10828887 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203564"xsd:string |
| http://purl.uniprot.org/citations/10828887 | http://purl.uniprot.org/core/author | "Hoffman B."xsd:string |
| http://purl.uniprot.org/citations/10828887 | http://purl.uniprot.org/core/author | "Liebermann D.A."xsd:string |
| http://purl.uniprot.org/citations/10828887 | http://purl.uniprot.org/core/author | "Bernardi R."xsd:string |
| http://purl.uniprot.org/citations/10828887 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10828887 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10828887 | http://purl.uniprot.org/core/pages | "2447-2454"xsd:string |
| http://purl.uniprot.org/citations/10828887 | http://purl.uniprot.org/core/title | "Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation."xsd:string |
| http://purl.uniprot.org/citations/10828887 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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