| http://purl.uniprot.org/citations/10830307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10830307 | http://www.w3.org/2000/01/rdf-schema#comment | "Basic fibroblast growth factor (bFGF) stimulates collagenase-3 synthesis in fetal rat osteoblast-enriched (Ob) cells. In this study we examined the mechanism of collagenase-3 regulation in Ob cells. bFGF at 0.6 nM or more increased the transcriptional rate of collagenase-3 by 3-to 7-fold. bFGF at 0.6 nM increased the activity of collagenase-3 promoter-luciferase reporter deletion constructs from -721 to -53 nucleotides transiently transfected into Ob cells by 3-to 5-fold. The minimal bFGF response was retained within the -53 to +28 sequence. Mutational analysis revealed that the bFGF effect was mediated through an activator protein-1 (AP-1)-binding site located at -48 to -42 nucleotides in the promoter. bFGF stimulated the binding of nuclear factors to the collagenase AP-1 site by 3-to 4-fold, as determined by electrophoretic mobility shift assays. Supershift analysis of nuclear extracts revealed that bFGF stimulates the occupancy of AP-1 site by c-Jun, JunB, JunD, c-Fos, FosB, and Fra2. In conclusion, bFGF increases collagenase-3 gene transcription, an effect mediated through an AP-1 site, due to the induction or activation of Jun and Fos family transcription factors. The stimulation of collagenase-3 synthesis by bFGF may be critical in mediating the actions of this growth factor in bone remodeling."xsd:string |
| http://purl.uniprot.org/citations/10830307 | http://purl.org/dc/terms/identifier | "doi:10.1210/endo.141.6.7504"xsd:string |
| http://purl.uniprot.org/citations/10830307 | http://purl.uniprot.org/core/author | "Varghese S."xsd:string |
| http://purl.uniprot.org/citations/10830307 | http://purl.uniprot.org/core/author | "Canalis E."xsd:string |
| http://purl.uniprot.org/citations/10830307 | http://purl.uniprot.org/core/author | "Rydziel S."xsd:string |
| http://purl.uniprot.org/citations/10830307 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10830307 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/10830307 | http://purl.uniprot.org/core/pages | "2185-2191"xsd:string |
| http://purl.uniprot.org/citations/10830307 | http://purl.uniprot.org/core/title | "Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site."xsd:string |
| http://purl.uniprot.org/citations/10830307 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/10830307 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10830307 |
| http://purl.uniprot.org/citations/10830307 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10830307 |
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| http://purl.uniprot.org/uniprot/D3ZLB7#attribution-2BE22EE05D9A44FB5D3FE68CED1FF4E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |
| http://purl.uniprot.org/uniprot/P51145#attribution-1C16D4784850D654BDD5E0F2E0745C4A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |
| http://purl.uniprot.org/uniprot/P51145#attribution-2BE22EE05D9A44FB5D3FE68CED1FF4E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |
| http://purl.uniprot.org/uniprot/P12841#attribution-1C16D4784850D654BDD5E0F2E0745C4A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |
| http://purl.uniprot.org/uniprot/P12841#attribution-2BE22EE05D9A44FB5D3FE68CED1FF4E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |
| http://purl.uniprot.org/uniprot/P17325#attribution-1C16D4784850D654BDD5E0F2E0745C4A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |
| http://purl.uniprot.org/uniprot/P17325#attribution-2BE22EE05D9A44FB5D3FE68CED1FF4E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |
| http://purl.uniprot.org/uniprot/P52909#attribution-1C16D4784850D654BDD5E0F2E0745C4A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |
| http://purl.uniprot.org/uniprot/P52909#attribution-2BE22EE05D9A44FB5D3FE68CED1FF4E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |
| http://purl.uniprot.org/uniprot/P24898#attribution-1C16D4784850D654BDD5E0F2E0745C4A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |
| http://purl.uniprot.org/uniprot/P24898#attribution-2BE22EE05D9A44FB5D3FE68CED1FF4E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10830307 |