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| http://purl.uniprot.org/citations/10831043 | http://www.w3.org/2000/01/rdf-schema#comment | "Two maternal-effect grandchildless (gs) mutations of Drosophila melanogaster, gs(1)N26 and gs(1)N441, cause delay in nuclear arrival at the polar plasm. In mutant embryos, polar plasm loses its ability to induce pole cells during retarded nuclear migration to the posterior pole of embryos. In the present study, it was shown that in N26 and N441 embryos, mitochondrial large rRNA (mtlrRNA), an essential factor for pole cell formation, is delocalized during the delay in nuclear arrival. This suggests that the loss of mtlrRNA causes failure of the mutants to form pole cells. Furthermore, it was shown that all of the other polar plasm components examined, namely Vasa protein, Germ cell-less protein, nanos mRNA and Polar granule component RNA start to be delocalized during the delay in nuclear arrival. This suggests that polar plasm integrity is not maintained in mutant embryos. It was finally shown that Vas is also delocalized in embryos that are inhibited to form pole cells by reducing the amount of mtlrRNA. This indicates that the segregation of polar plasm into pole cells is required to maintain polar plasm integrity. The mechanism regulating polar plasm integrity in embryos is discussed."xsd:string |
| http://purl.uniprot.org/citations/10831043 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1440-169x.2000.00482.x"xsd:string |
| http://purl.uniprot.org/citations/10831043 | http://purl.uniprot.org/core/author | "Iida T."xsd:string |
| http://purl.uniprot.org/citations/10831043 | http://purl.uniprot.org/core/author | "Kobayashi S."xsd:string |
| http://purl.uniprot.org/citations/10831043 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10831043 | http://purl.uniprot.org/core/name | "Dev Growth Differ"xsd:string |
| http://purl.uniprot.org/citations/10831043 | http://purl.uniprot.org/core/pages | "53-60"xsd:string |
| http://purl.uniprot.org/citations/10831043 | http://purl.uniprot.org/core/title | "Delocalization of polar plasm components caused by grandchildless mutations, gs(1)N26 and gs(1)N441, in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/10831043 | http://purl.uniprot.org/core/volume | "42"xsd:string |
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