| http://purl.uniprot.org/citations/10835355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10835355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10835355 | http://www.w3.org/2000/01/rdf-schema#comment | "The Saccharomyces cerevisiae protein kinase Rim15 was identified previously as a component of the Ras/cAMP pathway acting immediately downstream of cAMP-dependent protein kinase (cAPK) to control a broad range of adaptations in response to nutrient limitation. Here, we show that the zinc finger protein Gis1 acts as a dosage-dependent suppressor of the rim15Delta defect in nutrient limitation-induced transcriptional derepression of SSA3. Loss of Gis1 results in a defect in transcriptional derepression upon nutrient limitation of various genes that are negatively regulated by the Ras/cAMP pathway (e.g. SSA3, HSP12 and HSP26). Tests of epistasis as well as transcriptional analyses of Gis1-dependent expression indicate that Gis1 acts in this pathway downstream of Rim15 to mediate transcription from the previously identified post-diauxic shift (PDS) element. Accordingly, deletion of GIS1 partially suppresses, and overexpression of GIS1 exacerbates the growth defect of mutant cells that are compromised for cAPK activity. Moreover, PDS element-driven expression, which is negatively regulated by the Ras/cAMP pathway and which is induced upon nutrient limitation, is almost entirely dependent on the presence of Gis1."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.11.2569"xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.11.2569"xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/author | "Buerckert N."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/author | "Buerckert N."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/author | "Pedruzzi I."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/author | "Pedruzzi I."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/author | "De Virgilio C."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/author | "De Virgilio C."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/author | "Egger P."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/author | "Egger P."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/pages | "2569-2579"xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/pages | "2569-2579"xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/title | "Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/title | "Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1."xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10835355 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10835355 |
| http://purl.uniprot.org/citations/10835355 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10835355 |