| http://purl.uniprot.org/citations/10837920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10837920 | http://www.w3.org/2000/01/rdf-schema#comment | "Establishment of long-term potentiation (LTP) at perforant path synapses is highly correlated with increased expression of Egr and AP-1 transcription factors in rat dentate gyrus granule cells. We have investigated whether increased transcription factor levels are reflected in increased transcription factor activity by assessing Egr and AP-1 DNA binding activity using gel shift assays. LTP produced an increase in binding to the Egr element, which was NMDA receptor-dependent and correlated closely with our previously reported increase in Egr-1 (zif/268) protein levels. Supershift analysis confirmed involvement of Egr-1, but not Egr-2 in the DNA binding activity. AP-1 DNA binding was also rapidly elevated in parallel with protein levels, however, the peak increase in activity was delayed until 4 h, a time point when we have previously shown that only jun-D protein was elevated. These data indicate that binding of Egr-1 and AP-1 to their response elements is increased in two phases. This may result in activation of distinct banks of target genes which contribute to the establishment of persistent LTP."xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0169-328x(00)00061-9"xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/author | "Williams J.M."xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/author | "Abraham W.C."xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/author | "Mason-Parker S.E."xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/author | "Tate W.P."xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/author | "Wilce P.A."xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/author | "Beckmann A.M."xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/name | "Brain Res Mol Brain Res"xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/pages | "258-266"xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/title | "Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation."xsd:string |
| http://purl.uniprot.org/citations/10837920 | http://purl.uniprot.org/core/volume | "77"xsd:string |
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