| http://purl.uniprot.org/citations/10838083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10838083 | http://www.w3.org/2000/01/rdf-schema#comment | "In the Wnt/Wingless pathway, accumulation of beta-catenin/Armadillo protein is a key regulatory step. Vertebrate Axin is a negative regulator of Wnt signaling, promoting glycogen synthase kinase-3beta-mediated phosphorylation of beta-catenin and thereby destabilizing beta-catenin. Using Drosophila cell culture systems, we demonstrated that a Drosophila homolog of Axin (Daxin) inhibits Wingless-induced Armadillo accumulation and Drosophila T-cell factor-dependent transcription induced by Wingless, Dishevelled, and Armadillo. The carboxy-terminal portion of Daxin is not essential for the inhibitory activity, but a mutant only consisting of this portion behaves as a dominant-negative protein. Moreover, interactions between Daxin and Zeste-white 3, Armadillo, Dishevelled, protein phosphatase 2A and Daxin itself were shown, providing direct evidence that Daxin is a scaffold protein in the Wingless pathway."xsd:string |
| http://purl.uniprot.org/citations/10838083 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(00)01601-x"xsd:string |
| http://purl.uniprot.org/citations/10838083 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/10838083 | http://purl.uniprot.org/core/author | "Matsuda Y."xsd:string |
| http://purl.uniprot.org/citations/10838083 | http://purl.uniprot.org/core/author | "Ishimoto A."xsd:string |
| http://purl.uniprot.org/citations/10838083 | http://purl.uniprot.org/core/author | "Yanagawa S."xsd:string |
| http://purl.uniprot.org/citations/10838083 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10838083 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/10838083 | http://purl.uniprot.org/core/pages | "189-194"xsd:string |
| http://purl.uniprot.org/citations/10838083 | http://purl.uniprot.org/core/title | "Biochemical characterization of the Drosophila axin protein."xsd:string |
| http://purl.uniprot.org/citations/10838083 | http://purl.uniprot.org/core/volume | "474"xsd:string |
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| http://purl.uniprot.org/uniprot/P18824#attribution-06CF4401629D6FECB397AD7EE98870DF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10838083 |
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