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http://purl.uniprot.org/citations/10841574http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10841574http://www.w3.org/2000/01/rdf-schema#comment"A prospective study of high-risk commercial sex workers in Senegal has shown that HIV-2 infection may reduce the risk of subsequent HIV-1 infection; these findings have been confirmed and extended, now with 13 years of observation. While exploring the biological mechanisms behind this natural protection, we found that a significant proportion of peripheral blood mononuclear cells obtained from HIV-2-infected subjects resisted in vitro challenge with CCR5-dependent HIV-1 viruses but not CXCR4-dependent viruses. High levels of beta-chemokines, the natural ligands of the CCR5 coreceptor, were correlated with low levels of viral replication, and resistance was abrogated by antibodies to beta-chemokines. Our results suggest that beta-chemokine-mediated resistance may be an important correlate of HIV protection against HIV-1 infection and relevant to HIV vaccine design."xsd:string
http://purl.uniprot.org/citations/10841574http://purl.org/dc/terms/identifier"doi:10.1073/pnas.97.12.6797"xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/author"Schwartz D."xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/author"Mboup S."xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/author"Kokkotou E.G."xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/author"Mani I."xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/author"Gueye-Ndiaye A."xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/author"Kanki P.J."xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/author"Sankale J.L."xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/author"Essex M.E."xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/pages"6797-6802"xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/title"In vitro correlates of HIV-2-mediated HIV-1 protection."xsd:string
http://purl.uniprot.org/citations/10841574http://purl.uniprot.org/core/volume"97"xsd:string
http://purl.uniprot.org/citations/10841574http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10841574
http://purl.uniprot.org/citations/10841574http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10841574
http://purl.uniprot.org/uniprot/P10147#attribution-05CE0DE4448EBB3309770FA4CDBF37E2http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/10841574
http://purl.uniprot.org/uniprot/P13501#attribution-05CE0DE4448EBB3309770FA4CDBF37E2http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/10841574
http://purl.uniprot.org/uniprot/P13236#attribution-05CE0DE4448EBB3309770FA4CDBF37E2http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/10841574