| http://purl.uniprot.org/citations/10843844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10843844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10843844 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of multivalent glycoconjugates by lectins often leads to the formation of cross-linked complexes. Type I cross-links, which are one-dimensional, are formed by a divalent lectin and a divalent glycoconjugate. Type II cross-links, which are two or three-dimensional, occur when a lectin or glycoconjugate has a valence greater than two. Type II complexes are a source of additional specificity, since homogeneous type II complexes are formed in the presence of mixtures of lectins and glycoconjugates. This additional specificity is thought to become important when a lectin interacts with clusters of glycoconjugates, e.g. as is present on the cell surface. The cryst1al structure of the Glc/Man binding legume lectin FRIL in complex with a trisaccharide provides a molecular snapshot of how weak protein-protein interactions, which are not observed in solution, can become important when a cross-linked complex is formed. In solution, FRIL is a divalent dimer, but in the crystal FRIL forms a tetramer, which allows for the formation of an intricate type II cross-linked complex with the divalent trisaccharide. The dependence on weak protein-protein interactions can ensure that a specific type II cross-linked complex and its associated specificity can occur only under stringent conditions, which explains why lectins are often found forming higher-order oligomers."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.2000.3785"xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.2000.3785"xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/author | "Wyns L."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/author | "Wyns L."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/author | "Loris R."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/author | "Loris R."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/author | "Chrispeels M.J."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/author | "Chrispeels M.J."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/author | "Hamelryck T.W."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/author | "Hamelryck T.W."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/author | "Moore J.G."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/author | "Moore J.G."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/pages | "875-883"xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/pages | "875-883"xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/title | "The role of weak protein-protein interactions in multivalent lectin-carbohydrate binding: crystal structure of cross-linked FRIL."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/title | "The role of weak protein-protein interactions in multivalent lectin-carbohydrate binding: crystal structure of cross-linked FRIL."xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/volume | "299"xsd:string |
| http://purl.uniprot.org/citations/10843844 | http://purl.uniprot.org/core/volume | "299"xsd:string |