| http://purl.uniprot.org/citations/10848613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10848613 | http://www.w3.org/2000/01/rdf-schema#comment | "Latent transforming growth factor beta (TGF-beta) binding protein 2 (LTBP-2) is an integral component of elastin-containing microfibrils. We studied the expression of LTBP-2 in the developing mouse and rat by in situ hybridization, using tropoelastin expression as a marker of tissues participating in elastic fiber formation. LTBP-2 colocalized with tropoelastin within the perichondrium, lung, dermis, large arterial vessels, epicardium, pericardium, and heart valves at various stages of rodent embryonic development. Both LTBP-2 and tropoelastin expression were seen throughout the lung parenchyma and within the cortex of the spleen in the young adult mouse. In the testes, LTBP-2 expression was seen within lumenal cells of the epididymis in the absence of tropoelastin. Collectively, these results imply that LTBP-2 plays a structural role within elastic fibers in most cases. To investigate its importance in development, mice with a targeted disruption of the Ltbp2 gene were generated. Ltbp2(-/-) mice die between embryonic day 3.5 (E3.5) and E6.5. LTBP-2 expression was not detected by in situ hybridization in E6.5 embryos but was detected in E3.5 blastocysts by reverse transcription-PCR. These results are not consistent with the phenotypes of TGF-beta knockout mice or mice with knockouts of other elastic fiber proteins, implying that LTBP-2 performs a yet undiscovered function in early development, perhaps in implantation."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.13.4879-4887.2000"xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/author | "Rosenbloom J."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/author | "Mecham R.P."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/author | "Shipley J.M."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/author | "Shapiro S.D."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/author | "Bonadio J."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/author | "Segade F."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/author | "Frankfater C."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/author | "Maus E."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/author | "Baumann M.L."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/author | "McCarthy R.T."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/pages | "4879-4887"xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/title | "Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development."xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10848613 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10848613 |
| http://purl.uniprot.org/citations/10848613 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10848613 |
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| http://purl.uniprot.org/uniprot/#_A0A0J9YV95-mappedCitation-10848613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10848613 |
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| http://purl.uniprot.org/uniprot/#_D3Z0U1-mappedCitation-10848613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10848613 |