| http://purl.uniprot.org/citations/10848616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10848616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10848616 | http://www.w3.org/2000/01/rdf-schema#comment | "The DAX-1 (NR0B1) gene encodes an unusual member of the nuclear hormone receptor superfamily which acts as a transcriptional repressor. Mutations in the human DAX-1 gene cause X-linked adrenal hypoplasia congenita (AHC) associated with hypogonadotropic hypogonadism (HHG). We have studied the intracellular localization of the DAX-1 protein in human adrenal cortex and mouse Leydig tumor cells and found it to be both nuclear and cytoplasmic. A significant proportion of DAX-1 is associated with polyribosomes and is found complexed with polyadenylated RNA. DAX-1 directly binds to RNA, two domains within the protein being responsible for cooperative binding activity and specificity. Mutations in DAX-1 found in AHC-HHG patients significantly impair RNA binding. These findings reveal that DAX-1 plays multiple regulatory roles at the transcriptional and posttranscriptional levels."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.13.4910-4921.2000"xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.13.4910-4921.2000"xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/author | "Hindelang C."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/author | "Hindelang C."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/author | "Lalli E."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/author | "Lalli E."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/author | "Ohe K."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/author | "Ohe K."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/author | "Sassone-Corsi P."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/author | "Sassone-Corsi P."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/pages | "4910-4921"xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/pages | "4910-4921"xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/title | "Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/title | "Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA."xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10848616 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10848616 |
| http://purl.uniprot.org/citations/10848616 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10848616 |