| http://purl.uniprot.org/citations/10851066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10851066 | http://www.w3.org/2000/01/rdf-schema#comment | "Steroid hormones play key roles in regulating cell proliferation and differentiation in targeting tissues. However, in advanced cancers, the steroid hormone regulation is frequently attenuated through a yet unknown mechanism even in the presence of functional steroid hormone receptors. We investigate the functional role of tyrosine phosphorylation signaling in the hormone-refractory growth of human prostate tumors. Initial studies demonstrate that the androgen-responsive phenotype of human prostate cancer cells associates with a low phosphotyrosine (p-Tyr) level of ErbB-2, which is regulated by cellular prostatic acid phosphatase (PAcP), a protein tyrosine phosphatase. In prostate cancer cells, the p-Tyr level, but not the protein level, of ErbB-2 inversely correlates with the androgen-responsiveness of cell proliferation. Androgen-stimulated cell growth concurs with a down-regulation of cellular PAcP, an elevated p-Tyr level of ErbB-2, and the activation of mitogen-activated protein kinases. Furthermore, only the ErbB-2 inhibitor AG 879, but not the EGFR inhibitor AG 1478, abolishes androgen-induced cell proliferation. Forced expression of ErbB-2 can also attenuate androgen promotion of cell growth. Data taken collectively conclude that in human prostate cancer cells, the tyrosine phosphorylation of ErbB-2 regulated by cellular PAcP plays a key role in regulating androgen-mediated proliferation signaling. Oncogene (2000)."xsd:string |
| http://purl.uniprot.org/citations/10851066 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1203576"xsd:string |
| http://purl.uniprot.org/citations/10851066 | http://purl.uniprot.org/core/author | "Lee M.S."xsd:string |
| http://purl.uniprot.org/citations/10851066 | http://purl.uniprot.org/core/author | "Meng T.C."xsd:string |
| http://purl.uniprot.org/citations/10851066 | http://purl.uniprot.org/core/author | "Lin M.F."xsd:string |
| http://purl.uniprot.org/citations/10851066 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10851066 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10851066 | http://purl.uniprot.org/core/pages | "2664-2677"xsd:string |
| http://purl.uniprot.org/citations/10851066 | http://purl.uniprot.org/core/title | "Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cells."xsd:string |
| http://purl.uniprot.org/citations/10851066 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10851066 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10851066 |
| http://purl.uniprot.org/citations/10851066 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10851066 |
| http://purl.uniprot.org/uniprot/P04626#attribution-4AC3F67CE2A0E12CF3C7265B06491E62 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10851066 |