| http://purl.uniprot.org/citations/10852383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10852383 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to investigate whether polymorphisms in the tumor necrosis factor (TNF) and HLA-DRB1 gene regions are independently associated with rheumatoid arthritis (RA) in a population from Lugo region of northwestern Spain. RA patients (n=179) attending hospital outpatient clinics in Lugo, northwestern Spain and matched controls (n=145) were recruited. RA susceptibility in this population was predominantly associated with DRB1*0401, while erosive disease was associated with HLA-DRB1*0101 and DRB1*04. The increase in DRB1*04 was accounted for by an increase in DRB1*0404 and *0405 but not *0401 frequencies. In contrast, *0401 frequency was significantly increased in seropositive patients. The rheumatoid arthritis shared epitope (SE) was associated with increased risk for seropositive and erosive disease and this appeared to operate in a dose-dependent manner. Logistic regression analyses revealed that the TNF microsatellite markers TNFc1 and b3 were associated with RA independently of DRB1*04 and the SE. Carriage of a TNF c1 allele provided an increased risk of RA in SE-negative and SE-heterozygous individuals. TNFc1 and TNFb3 were not associated with erosive or seropositive disease. In contrast, TNF a2 was significantly associated with erosive disease which was independent of DRB1*04 and the SE. Further studies will be needed to establish why (TNFc1) polymorphism seemingly associated with low TNFalpha production, is a risk factor for RA."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.org/dc/terms/identifier | "doi:10.1034/j.1399-0039.2000.550405.x"xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/author | "Thomson W."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/author | "Gonzalez-Gay M.A."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/author | "Hajeer A.H."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/author | "Mattey D.L."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/author | "Ollier W.E."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/author | "Poulton K."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/author | "Dababneh A."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/author | "Garcia-Porrua C."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/author | "Makki R.F."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/pages | "319-325"xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/title | "Different gene loci within the HLA-DR and TNF regions are independently associated with susceptibility and severity in Spanish rheumatoid arthritis patients."xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/10852383 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10852383 |
| http://purl.uniprot.org/citations/10852383 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10852383 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-10852383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10852383 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-10852383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10852383 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-10852383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10852383 |
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