| http://purl.uniprot.org/citations/10856240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10856240 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10856240 | http://www.w3.org/2000/01/rdf-schema#comment | "Evi-1 encodes a nuclear protein involved in leukemic transformation of hematopoietic cells. Evi-1 possesses two sets of zinc finger motifs separated into two domains, and its characteristics as a transcriptional regulator have been described. Here we show that Evi-1 acts as an inhibitor of c-Jun N-terminal kinase (JNK), a class of mitogen-activated protein kinases implicated in stress responses of cells. Evi-1 physically interacts with JNK, although it does not affect its phosphorylation. This interaction is required for inhibition of JNK. Evi-1 protects cells from stress-induced cell death with dependence on the ability to inhibit JNK. These results reveal a novel function of Evi-1, which provides evidence for inhibition of JNK by a nuclear oncogene product. Evi-1 blocks cell death by selectively inhibiting JNK, thereby contributing to oncogenic transformation of cells."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.12.2958"xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.12.2958"xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Hirai H."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Hirai H."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Mitani K."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Mitani K."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Moriguchi T."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Moriguchi T."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Yamagata T."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Yamagata T."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Yazaki Y."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Yazaki Y."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Nishida E."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Nishida E."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Kurokawa M."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Kurokawa M."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Izutsu K."xsd:string |
| http://purl.uniprot.org/citations/10856240 | http://purl.uniprot.org/core/author | "Izutsu K."xsd:string |