| http://purl.uniprot.org/citations/10856243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10856243 | http://www.w3.org/2000/01/rdf-schema#comment | "The POU domain transcription factor Oct-6 is a major regulator of Schwann cell differentiation and myelination. During nerve development and regeneration, expression of Oct-6 is under the control of axonal signals. Identification of the cis-acting elements necessary for Oct-6 gene regulation is an important step in deciphering the complex signalling between Schwann cells and axons governing myelination. Here we show that a fragment distal to the Oct-6 gene, containing two DNase I-hypersensitive sites, acts as the Oct-6 Schwann cell-specific enhancer (SCE). The SCE is sufficient to drive spatially and temporally correct expression, during both normal peripheral nerve development and regeneration. We further demonstrate that a tagged version of Oct-6, driven by the SCE, rescues the peripheral nerve phenotype of Oct-6-deficient mice. Thus, our isolation and characterization of the Oct-6 SCE provides the first description of a cis-acting genetic element that responds to converging signalling pathways to drive myelination in the peripheral nervous system."xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.12.2992"xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/author | "Zwart R."xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/author | "Meijer D."xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/author | "Mandemakers W."xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/author | "Grosveld F."xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/author | "Jaegle M."xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/author | "Visser P."xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/author | "Walbeehm E."xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/pages | "2992-3003"xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/title | "A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regeneration."xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10856243 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10856243 |
| http://purl.uniprot.org/citations/10856243 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10856243 |
| http://purl.uniprot.org/uniprot/#_P56693-mappedCitation-10856243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10856243 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPM4-mappedCitation-10856243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10856243 |
| http://purl.uniprot.org/uniprot/#_E9QK82-mappedCitation-10856243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10856243 |
| http://purl.uniprot.org/uniprot/#_Q86SQ4-mappedCitation-10856243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10856243 |
| http://purl.uniprot.org/uniprot/#_P21952-mappedCitation-10856243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10856243 |
| http://purl.uniprot.org/uniprot/#_P27573-mappedCitation-10856243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10856243 |
| http://purl.uniprot.org/uniprot/#_P51532-mappedCitation-10856243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10856243 |
| http://purl.uniprot.org/uniprot/#_Q03052-mappedCitation-10856243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10856243 |