| http://purl.uniprot.org/citations/10860850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10860850 | http://www.w3.org/2000/01/rdf-schema#comment | "We have compared the coupling of human alpha(1A)-, alpha(1B)-, and alpha(1D)-adrenoceptors (expressed at approximately 2000 fmol/mg protein in Chinese hamster ovary cells) to cellular growth promotion (as assessed by [(3)H]thymidine incorporation) and related signaling mechanisms. Maximum elevation of intracellular Ca(2+) by the three subtypes occurred with the rank order alpha(1A) (1691 nM) > alpha(1D) (1215 nM) > alpha(1B) (360 nM). In contrast, activation of the ERK, JNK, and p38 forms of mitogen-activated protein kinases occurred with the rank order alpha(1D) > alpha(1A) > alpha(1B). alpha(1A)-Adrenoceptor stimulation inhibited basal and growth factor-stimulated [(3)H]thymidine incorporation by 74%, and this was mitigated by p38 inhibition. In contrast, alpha(1D)-adrenoceptor stimulation enhanced cellular growth by 136%, and this was blocked by two distinct inhibitors of ERK activation. We conclude that within a given cell type alpha(1)-adrenoceptor subtypes can have opposite effects on cellular growth, although their proximal signal transduction displays only quantitative differences."xsd:string |
| http://purl.uniprot.org/citations/10860850 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2000.2850"xsd:string |
| http://purl.uniprot.org/citations/10860850 | http://purl.uniprot.org/core/author | "Alexandrov A."xsd:string |
| http://purl.uniprot.org/citations/10860850 | http://purl.uniprot.org/core/author | "Michel M.C."xsd:string |
| http://purl.uniprot.org/citations/10860850 | http://purl.uniprot.org/core/author | "Goepel M."xsd:string |
| http://purl.uniprot.org/citations/10860850 | http://purl.uniprot.org/core/author | "Keffel S."xsd:string |
| http://purl.uniprot.org/citations/10860850 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10860850 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/10860850 | http://purl.uniprot.org/core/pages | "906-911"xsd:string |
| http://purl.uniprot.org/citations/10860850 | http://purl.uniprot.org/core/title | "alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells."xsd:string |
| http://purl.uniprot.org/citations/10860850 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/10860850 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10860850 |
| http://purl.uniprot.org/citations/10860850 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10860850 |
| http://purl.uniprot.org/uniprot/P35348#attribution-19EE5DDAEDD82C66BBD52911B2C09AE8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10860850 |
| http://purl.uniprot.org/uniprot/P25100#attribution-19EE5DDAEDD82C66BBD52911B2C09AE8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10860850 |