| http://purl.uniprot.org/citations/10864042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10864042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10864042 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemical modifications and processing of the 18S, 5.8S, and 25S ribosomal RNAs from the 35S pre-ribosomal RNA depend on an important set of small nucleolar ribonucleoprotein particles (snoRNPs). Genetic depletion of yeast Gar1p, an essential common component of H/ACA snoRNPs, leads to inhibition of uridine isomerizations to pseudo-uridines on the 35S pre-rRNA and of the early pre-rRNA cleavages at sites A1 and A2, resulting in a loss of mature 18S rRNA synthesis. To identify Gar1p functional partners, we screened for mutations that are synthetically lethal with a gar1 mutant allele encoding a Gar1p mutant protein lacking its two glycine/arginine-rich (GAR) domains. We identified a previously uncharacterized Saccharomyces cerevisiae open reading frame, YDR083W (now designated RRP8), that encodes a highly conserved protein containing motifs found in methyltransferases. Rrp8p localizes to the nucleolus. A yeast strain lacking this protein is viable at 30 degrees C but displays strong growth impairment at lower temperatures. In this strain, cleavage of the pre-rRNA at site A2 is strongly affected whereas cleavages at sites A0 and A1 are only slightly inhibited or delayed."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.org/dc/terms/identifier | "doi:10.1017/s1355838200992288"xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.org/dc/terms/identifier | "doi:10.1017/s1355838200992288"xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/author | "Henry Y."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/author | "Henry Y."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/author | "Vanrobays E."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/author | "Vanrobays E."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/author | "Bousquet-Antonelli C."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/author | "Bousquet-Antonelli C."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/author | "Caizergues-Ferrer M."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/author | "Caizergues-Ferrer M."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/author | "Gelugne J.P."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/author | "Gelugne J.P."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/pages | "826-843"xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/pages | "826-843"xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/title | "Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/title | "Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2."xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/10864042 | http://purl.uniprot.org/core/volume | "6"xsd:string |