| http://purl.uniprot.org/citations/10866662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10866662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10866662 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe the cloning and characterization of a new family of nuclear receptor coregulators (NRCs) which modulate the function of nuclear hormone receptors in a ligand-dependent manner. NRCs are expressed as alternatively spliced isoforms which may exhibit different intrinsic activities and receptor specificities. The NRCs are organized into several modular structures and contain a single functional LXXLL motif which associates with members of the steroid hormone and thyroid hormone/retinoid receptor subfamilies with high affinity. Human NRC (hNRC) harbors a potent N-terminal activation domain (AD1), which is as active as the herpesvirus VP16 activation domain, and a second activation domain (AD2) which overlaps with the receptor-interacting LXXLL region. The C-terminal region of hNRC appears to function as an inhibitory domain which influences the overall transcriptional activity of the protein. Our results suggest that NRC binds to liganded receptors as a dimer and this association leads to a structural change in NRC resulting in activation. hNRC binds CREB-binding protein (CBP) with high affinity in vivo, suggesting that hNRC may be an important functional component of a CBP complex involved in mediating the transcriptional effects of nuclear hormone receptors."xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.14.5048-5063.2000"xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.20.14.5048-5063.2000"xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/author | "Mahajan M.A."xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/author | "Mahajan M.A."xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/author | "Samuels H.H."xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/author | "Samuels H.H."xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/pages | "5048-5063"xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/pages | "5048-5063"xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/title | "A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/title | "A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/10866662 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10866662 |
| http://purl.uniprot.org/citations/10866662 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10866662 |
| http://purl.uniprot.org/citations/10866662 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10866662 |
| http://purl.uniprot.org/citations/10866662 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10866662 |
| http://purl.uniprot.org/uniprot/P63059 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10866662 |
| http://purl.uniprot.org/uniprot/Q92793 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10866662 |