| http://purl.uniprot.org/citations/10867001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10867001 | http://www.w3.org/2000/01/rdf-schema#comment | "Acid sphingomyelinase (ASM) is reported to have an essential function in stress-induced apoptosis although the physiological function of ASM in receptor-triggered apoptosis is unknown. Here, we delineate a pivotal role for ASM in CD95-triggered apoptosis of peripheral lymphocytes or hepatocytes in vivo. We employed intravenous injection of anti-CD4 antibodies or phytohemagglutinin that was previously shown to result in apoptosis of peripheral blood lymphocytes or hepatocytes via the endogenous CD95/CD95 ligand system. Our results demonstrate a high susceptibility in normal mice whereas ASM knock-out mice fail to immunodeplete T cells or develop autoimmune-like hepatitis. Likewise, ASM-deficient mice or hepatocytes and splenocytes ex vivo manifest resistance to anti-CD95 treatment. These results provide in vivo evidence for an important physiological function of ASM in CD95-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m002957200"xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/author | "Ferlinz K."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/author | "Fuks Z."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/author | "Grassme H."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/author | "Gulbins E."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/author | "Kolesnick R."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/author | "Paris F."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/author | "Weller M."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/author | "Riehle A."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/author | "Kirschnek S."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/pages | "27316-27323"xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/title | "CD95-mediated apoptosis in vivo involves acid sphingomyelinase."xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/10867001 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10867001 |
| http://purl.uniprot.org/citations/10867001 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10867001 |
| http://purl.uniprot.org/uniprot/#_Q3UG03-mappedCitation-10867001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10867001 |
| http://purl.uniprot.org/uniprot/#_Q04519-mappedCitation-10867001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10867001 |
| http://purl.uniprot.org/uniprot/#_Q3UEE0-mappedCitation-10867001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10867001 |
| http://purl.uniprot.org/uniprot/#_Q8K011-mappedCitation-10867001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10867001 |
| http://purl.uniprot.org/uniprot/Q04519 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10867001 |
| http://purl.uniprot.org/uniprot/Q8K011 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10867001 |