| http://purl.uniprot.org/citations/10869404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10869404 | http://www.w3.org/2000/01/rdf-schema#comment | "Opioid peptides long have been hypothesized to play a role in ethanol reinforcement. Neuropharmacological studies have shown that opioid receptor antagonists decrease ethanol self-administration in rodents and prevent relapse in humans. However, the exact mechanism for such powerful effects has remained elusive. The availability of mu-opioid receptor knockout mice has made possible the direct examination of the role of the mu-opioid receptor in mediating ethanol self-administration. In the present experiments, both nosepoke and lever operant ethanol self-administration and several tests of two bottle-choice ethanol drinking were studied in these genetically engineered mice. In no case did knockout mice show evidence of ethanol self-administration, and, in fact, these mice showed evidence of an aversion to ethanol under several experimental conditions. These data provide new evidence for a critical role for mu-opioid receptors in ethanol self-administration assessed with a variety of behavioral paradigms and new insights into the neuropharmacological basis for ethanol reinforcement."xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/author | "Roberts A.J."xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/author | "Kieffer B.L."xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/author | "Gold L.H."xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/author | "Koob G.F."xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/author | "Matthes H.W."xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/author | "Heyser C.J."xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/author | "McDonald J.S."xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/name | "J Pharmacol Exp Ther"xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/pages | "1002-1008"xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/title | "mu-Opioid receptor knockout mice do not self-administer alcohol."xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/10869404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10869404 |
| http://purl.uniprot.org/citations/10869404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10869404 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0Z2-mappedCitation-10869404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10869404 |
| http://purl.uniprot.org/uniprot/#_E9Q7D3-mappedCitation-10869404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10869404 |
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| http://purl.uniprot.org/uniprot/#_A1XGX2-mappedCitation-10869404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10869404 |
| http://purl.uniprot.org/uniprot/#_A4GE58-mappedCitation-10869404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10869404 |
| http://purl.uniprot.org/uniprot/#_E9Q270-mappedCitation-10869404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10869404 |