| http://purl.uniprot.org/citations/10878370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10878370 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of NY-ESO-1 in a high proportion of different human tumors makes this protein a very attractive vaccine target. NY-ESO-1 peptides, recognized by HLA-A2-restricted CTL, have recently been described. However, it remains unclear how efficiently tumors generate these epitopes, and whether peptide analogues can be used for optimal expansion and activation of NY-ESO-1-specific HLA-A2-restricted CTL. By generating unique CTL clones, we demonstrate that NY-ESO-1-positive tumor cells are efficiently killed by HLA-A2-restricted CTL specific for the peptide epitope NY-ESO-1 157-165. Presentation of this epitope is not affected by the presence or absence of the proteasome subunits low molecular proteins 2 and 7 and is not blocked by proteasome inhibitors, while it is impaired in the TAP-deficient cell line LBL 721.174. NY-ESO-1 157-165 peptide analogues were compared for their antigenicity and immunogenicity using PBL from melanoma patients. Three peptides, containing the carboxyl-terminal cysteine substituted for either valine, isoleucine, or leucine, were recognized at least 100 times more efficiently than the wild-type peptide by specific CTL. Peptide analogues were capable of stimulating the expansion of NY-ESO-1-specific CTL from PBL of melanoma patients much more efficiently than wild-type peptide. These findings define the processing requirements for the generation of the NY-ESO-1 157-165 epitope. Identification of highly antigenic NY-ESO-1 peptide analogues may be important for the development of vaccines capable of expanding NY-ESO-1-specific CTL in cancer patients."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.2.948"xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Knuth A."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Old L.J."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Nagata Y."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Stockert E."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Cerundolo V."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Chen J.L."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Dunbar P.R."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Chen Y.T."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Jager E."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Gileadi U."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Gnjatic S."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/author | "Panicali D.L."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/pages | "948-955"xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/title | "Identification of NY-ESO-1 peptide analogues capable of improved stimulation of tumor-reactive CTL."xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://purl.uniprot.org/core/volume | "165"xsd:string |
| http://purl.uniprot.org/citations/10878370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10878370 |
| http://purl.uniprot.org/citations/10878370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10878370 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4J279-mappedCitation-10878370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878370 |
| http://purl.uniprot.org/uniprot/#_A0A0K0K1A5-mappedCitation-10878370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878370 |