| http://purl.uniprot.org/citations/10878381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10878381 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations of Fas (lpr) or Fas ligand (gld) cause a limited lupus-like syndrome in B6 mice by interfering with the deletion of autoreactive B and/or T cells. A more generalized lupus syndrome reminiscent of that of MRL mice can be induced in nonautoimmune strains by pristane, which causes a nonspecific inflammatory response in the peritoneal cavity. We hypothesized that, as in MRL mice, the lpr and gld mutations might accelerate lupus in pristane-treated mice. Pristane-treated B6 mice developed anti-nRNP/Sm, Su, and ribosomal P Abs, but little anti-ssDNA or chromatin. In contrast, B6/lpr and B6/gld mice spontaneously developed anti-ssDNA/chromatin Abs, but not anti-nRNP/Sm/Su/ribosomal P. Unexpectedly, B6/lpr and B6/gld mice were highly resistant to the induction by pristane of IgM anti-ssDNA (2 wk) and IgG anti-nRNP/Sm/Su/ribosomal P autoantibodies (6 mo), suggesting that intact Fas signaling is necessary. Interestingly, pristane did not enhance IgG chromatin Ab production in B6/lpr or B6/gld mice, suggesting that it did not influence the production of autoantibodies that develop spontaneously in the setting of Fas deficiency. Pristane treatment also decreased lymphoproliferation in B6/lpr mice. Increased production of IL-12 was associated consistently with the production of anti-nRNP/Sm/Su/ribosomal P as well as anti-DNA/chromatin. In contrast, production of anti-DNA/chromatin Abs was associated with IL-6 overproduction in pristane-treated mice, but not in lpr mice. The data strongly support the idea that different subsets of autoantibodies are regulated differentially by cytokine stimulation and/or Fas signaling."xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.2.1036"xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/author | "Shaw M."xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/author | "Satoh M."xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/author | "Reeves W.H."xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/author | "Richards H.B."xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/author | "Shaheen V.M."xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/author | "Weintraub J.P."xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/pages | "1036-1043"xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/title | "Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus."xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://purl.uniprot.org/core/volume | "165"xsd:string |
| http://purl.uniprot.org/citations/10878381 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10878381 |
| http://purl.uniprot.org/citations/10878381 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10878381 |
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| http://purl.uniprot.org/uniprot/#_A0A494BBP5-mappedCitation-10878381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878381 |
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| http://purl.uniprot.org/uniprot/#_A1Y9B2-mappedCitation-10878381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878381 |
| http://purl.uniprot.org/uniprot/#_Q7TMV9-mappedCitation-10878381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878381 |
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| http://purl.uniprot.org/uniprot/#_P25446-mappedCitation-10878381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878381 |
| http://purl.uniprot.org/uniprot/#_Q544E9-mappedCitation-10878381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878381 |