| http://purl.uniprot.org/citations/10878807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10878807 | http://www.w3.org/2000/01/rdf-schema#comment | "von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome that is characterized by the development of multiple vascular tumors and is caused by inactivation of the von Hippel-Lindau protein (pVHL). Here we show that pVHL, through its beta-domain, binds directly to hypoxia-inducible factor (HIF), thereby targeting HIF for ubiquitination in an alpha-domain-dependent manner. This is the first function to be ascribed to the pVHL beta-domain. Furthermore, we provide the first direct evidence that pVHL has a function analogous to that of an F-box protein, namely, to recruit substrates to a ubiquitination machine. These results strengthen the link between overaccumulation of HIF and development of VHL disease."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.org/dc/terms/identifier | "doi:10.1038/35017054"xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/author | "Kim T.Y."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/author | "Hoffman M.A."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/author | "Ohh M."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/author | "Pavletich N."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/author | "Huang L.E."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/author | "Park C.W."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/author | "Chau V."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/author | "Ivan M."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/author | "Kaelin W.G."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/pages | "423-427"xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/title | "Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein."xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/10878807 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10878807 |
| http://purl.uniprot.org/citations/10878807 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10878807 |
| http://purl.uniprot.org/uniprot/#_A6NIX2-mappedCitation-10878807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878807 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-10878807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878807 |
| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-10878807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878807 |
| http://purl.uniprot.org/uniprot/#_P62837-mappedCitation-10878807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878807 |
| http://purl.uniprot.org/uniprot/#_Q15369-mappedCitation-10878807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878807 |
| http://purl.uniprot.org/uniprot/#_Q15370-mappedCitation-10878807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10878807 |