| http://purl.uniprot.org/citations/10878810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10878810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10878810 | http://www.w3.org/2000/01/rdf-schema#comment | "Wiskott-Aldrich syndrome protein (WASP) and N-WASP have emerged as key proteins connecting signalling cascades to actin polymerization. Here we show that the amino-terminal WH1 domain, and not the polyproline-rich region, of N-WASP is responsible for its recruitment to sites of actin polymerization during Cdc42-independent, actin-based motility of vaccinia virus. Recruitment of N-WASP to vaccinia is mediated by WASP-interacting protein (WIP), whereas in Shigella WIP is recruited by N-WASP. Our observations show that vaccinia and Shigella activate the Arp2/3 complex to achieve actin-based motility, by mimicking either the SH2/SH3-containing adaptor or Cdc42 signalling pathways to recruit the N-WASP-WIP complex. We propose that the N-WASP-WIP complex has a pivotal function in integrating signalling cascades that lead to actin polymerization."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.org/dc/terms/identifier | "doi:10.1038/35017080"xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.org/dc/terms/identifier | "doi:10.1038/35017080"xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Way M."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Way M."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Frischknecht F."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Frischknecht F."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Vincentelli R."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Vincentelli R."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Stewart D.M."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Stewart D.M."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Moreau V."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Moreau V."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Reckmann I."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Reckmann I."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Rabut G."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/author | "Rabut G."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/pages | "441-448"xsd:string |
| http://purl.uniprot.org/citations/10878810 | http://purl.uniprot.org/core/pages | "441-448"xsd:string |