| http://purl.uniprot.org/citations/10880523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10880523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10880523 | http://www.w3.org/2000/01/rdf-schema#comment | "The susceptibility to infections induced by Gram-negative bacteria is largely determined by innate immune responses to bacteria cell wall lipopolysaccharide (LPS). The stimulation of B cells by LPS enhances their antigen-presenting capacity and is accompanied by B cell proliferation and secretion of large quantities of LPS-neutralizing antibodies. Similar to macrophages and neutrophils, the LPS-induced activation of B cells is dependent on Toll-like receptor (TLR)4. Here, we demonstrate that the responses of B cells to LPS are also regulated by another TLR protein, RP105, which is predominantly expressed on mature B cells in mice and humans. The analysis of mice homozygous for the null mutation in the RP105 gene revealed impaired proliferative and humoral immune responses of RP105-deficient B cells to LPS. Using originally LPS-unresponsive Ba/F3 cells expressing exogenous TLR4 and RP105, we demonstrate the functional cooperation between TLR4 and RP105 in LPS-induced nuclear factor kappaB activation. These data suggest the existence of the TLR4-RP105 signaling module in the LPS-induced B cell activation."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.192.1.23"xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.192.1.23"xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Nagai Y."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Nagai Y."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Ogata H."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Ogata H."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Miyake K."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Miyake K."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Kimoto M."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Kimoto M."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Tarakhovsky A."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Tarakhovsky A."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Akashi S."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Akashi S."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Su I."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Su I."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Mecklenbraeuker I."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Mecklenbraeuker I."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Rajewsky K."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/author | "Rajewsky K."xsd:string |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10880523 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |