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http://purl.uniprot.org/citations/10882101http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10882101http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10882101http://www.w3.org/2000/01/rdf-schema#comment"The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negative mutant TAB2 impairs their activation by IL-1. IL-1 stimulates translocation of TAB2 from the membrane to the cytosol where it mediates the IL-1-dependent association of TAK1 with TRAF6. These results define TAB2 as an adaptor linking TAK1 and TRAF6 and as a mediator of TAK1 activation in the IL-1 signaling pathway."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.org/dc/terms/identifier"doi:10.1016/s1097-2765(00)80244-0"xsd:string
http://purl.uniprot.org/citations/10882101http://purl.org/dc/terms/identifier"doi:10.1016/s1097-2765(00)80244-0"xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Irie K."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Irie K."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Matsumoto K."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Matsumoto K."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Yamaguchi K."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Yamaguchi K."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Takaesu G."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Takaesu G."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Kishida S."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Kishida S."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Hiyama A."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Hiyama A."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Shibuya H."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Shibuya H."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Ninomiya-Tsuji J."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/author"Ninomiya-Tsuji J."xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/name"Mol. Cell"xsd:string
http://purl.uniprot.org/citations/10882101http://purl.uniprot.org/core/name"Mol. Cell"xsd:string