| http://purl.uniprot.org/citations/10887089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10887089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10887089 | http://www.w3.org/2000/01/rdf-schema#comment | "The daf-4 gene encodes a type II bone morphogenetic protein receptor in Caenorhabditis elegans that regulates dauer larva formation, body size and male tail patterning. The putative type I receptor partner for DAF-4 in regulating dauer larva formation is DAF-1. Genetic tests of the mechanism of activation of these receptors show that DAF-1 can signal in the absence of DAF-4 kinase activity. A daf-1 mutation enhances dauer formation in a daf-4 null background, whereas overexpression of daf-1 partially rescues a daf-4 mutant. DAF-1 alone cannot fully compensate for the loss of DAF-4 activity, indicating that nondauer development normally results from the activities of both receptors. DAF-1 signaling in the absence of a type II kinase is unique in the type I receptor family. The activity may be an evolutionary remnant, owing to daf-1's origin near the type I/type II divergence, or it may be an innovation that evolved in nematodes. daf-1 and daf-4 promoters both mediated expression of green fluorescent protein in the nervous system, indicating that a DAF-1/DAF-4 receptor complex may activate a neuronal signaling pathway. Signaling from a strong DAF-1/DAF-4 receptor complex or a weaker DAF-1 receptor alone may provide larvae with more precise control of the dauer/nondauer decision in a range of environmental conditions."xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.127.15.3337"xsd:string |
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| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/author | "Riddle D.L."xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/author | "Riddle D.L."xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/author | "Georgi L.L."xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/author | "Georgi L.L."xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/author | "Gunther C.V."xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/author | "Gunther C.V."xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/pages | "3337-3347"xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/pages | "3337-3347"xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/title | "A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development."xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/title | "A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development."xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/10887089 | http://purl.uniprot.org/core/volume | "127"xsd:string |
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| http://purl.uniprot.org/citations/10887089 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10887089 |
| http://purl.uniprot.org/citations/10887089 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10887089 |
| http://purl.uniprot.org/citations/10887089 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10887089 |