| http://purl.uniprot.org/citations/10892744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10892744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10892744 | http://www.w3.org/2000/01/rdf-schema#comment | "We disrupted the FOG-2 gene in mice to define its requirement in vivo. FOG-2(-/-) embryos die at midgestation with a cardiac defect characterized by a thin ventricular myocardium, common atrioventricular canal, and the tetralogy of Fallot malformation. Remarkably, coronary vasculature is absent in FOG-2(-/-) hearts. Despite formation of an intact epicardial layer and expression of epicardium-specific genes, markers of cardiac vessel development (ICAM-2 and FLK-1) are not detected, indicative of failure to activate their expression and/or to initiate the epithelial to mesenchymal transformation of epicardial cells. Transgenic reexpression of FOG-2 in cardiomyocytes rescues the FOG-2(-/-) vascular phenotype, demonstrating that FOG-2 function in myocardium is required and sufficient for coronary vessel development. Our findings provide the molecular inroad into the induction of coronary vasculature by myocardium in the developing heart."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80885-5"xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80885-5"xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Fujiwara Y."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Fujiwara Y."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Orkin S.H."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Orkin S.H."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Schinke M."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Schinke M."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Deconinck A.E."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Deconinck A.E."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Izumo S."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Izumo S."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Litovsky S.H."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Litovsky S.H."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Tevosian S.G."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/author | "Tevosian S.G."xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/10892744 | http://purl.uniprot.org/core/name | "Cell"xsd:string |