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http://purl.uniprot.org/citations/10894168http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10894168http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10894168http://www.w3.org/2000/01/rdf-schema#comment"That NK cell receptors engage fast-evolving MHC class I ligands suggests that they, too, evolve rapidly. To test this hypothesis, the structure and class I specificity of chimpanzee KIR and CD94:NKG2 receptors were determined and compared to their human counterparts. The KIR families are divergent, with only three KIR conserved between chimpanzees and humans. By contrast, CD94:NKG2 receptors are conserved. Whereas receptors for polymorphic class I are divergent, those for nonpolymorphic class I are conserved. Although chimpanzee and human NK cells exhibit identical receptor specificities for MHC-C, they are mediated by nonorthologous KIR. These results demonstrate the rapid evolution of NK cell receptor systems and imply that "catching up" with class I is not the only force driving this evolution."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)80219-8"xsd:string
http://purl.uniprot.org/citations/10894168http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)80219-8"xsd:string
http://purl.uniprot.org/citations/10894168http://purl.org/dc/terms/identifier"doi:10.1016/S1074-7613(00)80219-8"xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Parham P."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Parham P."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Weidenbach K."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Weidenbach K."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Lanier L.L."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Lanier L.L."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Canavez F."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Canavez F."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Shum B.P."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Shum B.P."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Valiante N.M."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Valiante N.M."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Khakoo S.I."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Khakoo S.I."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Rajalingam R."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Rajalingam R."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Cooper S.L."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Cooper S.L."xsd:string
http://purl.uniprot.org/citations/10894168http://purl.uniprot.org/core/author"Flodin L."xsd:string