| http://purl.uniprot.org/citations/10894793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10894793 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the role of renal endothelin-1 (ET-1) synthesis in water-sodium homeostasis, we measured mRNA expressions, protein levels, enzyme activity, and receptor binding of the renal ET-1 system in a DOCA- and salt-treated rat model. Male Wistar rats were divided into control and DOCA- and salt-treated (DOCA-Salt) groups. The DOCA-Salt group received 25 mg/kg body wt DOCA and was maintained on 1% NaCl drinking water. Rats were killed on days 1, 2, 4, and 10 of the experiment. Urinary ET-1-like immunoreactivity significantly increased from the second day in the DOCA-Salt group and correlated well with the urinary sodium excretion rate (r = 0.81, P < 0.001). Renal endothelin-converting enzyme (ECE) activity, ET-1, and ECE-1 mRNA expressions were significantly increased in the renal medullary area of DOCA-Salt rats. In situ hybridization and immunohistochemical studies showed that the increase in ET-1 synthesis was mainly localized in the inner medullary collecting ducts. The maximum binding of endothelin B receptor also increased from the second day in the renal medulla of the DOCA-Salt group. Our results suggest that renal medullary synthesized ET-1 may be a natriuretic factor and may participate in the intrarenal regulation of water and salt homeostasis in prehypertensive DOCA-and salt-treated rats."xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.2000.279.1.f112"xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/author | "Lee Y.J."xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/author | "Tsai J.H."xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/author | "Hsu C.H."xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/author | "Hsieh T.J."xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/author | "Lin S.R."xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/author | "Shin S.J."xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/author | "Lai Y.H."xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/name | "Am J Physiol Renal Physiol"xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/pages | "F112-21"xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/title | "Increased renal medullary endothelin-1 synthesis in prehypertensive DOCA- and salt-treated rats."xsd:string |
| http://purl.uniprot.org/citations/10894793 | http://purl.uniprot.org/core/volume | "279"xsd:string |
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