| http://purl.uniprot.org/citations/10899912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10899912 | http://www.w3.org/2000/01/rdf-schema#comment | "The dominant lymphocytes in human and murine implantation sites are transient, pregnancy-associated uterine natural killer (uNK) cells. These cells are a major source of interferon (IFN)-gamma. Implantation sites in mice lacking uNK cells (alymphoid recombinase activating gene [RAG]-2(-/)-common cytokine receptor chain gamma [gamma(c)](-/)-) or IFN-gamma signaling (IFN-gamma(-/)- or IFN-gammaRalpha(-/)-) fail to initiate normal pregnancy-induced modification of decidual arteries and display hypocellularity or necrosis of decidua. To investigate the functions of uNK cell-derived IFN-gamma during pregnancy, RAG-2(-/)-gamma(c)(-/)- females were engrafted with bone marrow from IFN-gamma(-/)-mice, IFN-gamma signal-disrupted mice (IFN-gammaRalpha(-/)- or signal transducer and activator of transcription [Stat]-1(-/)-), or from mice able to establish normal uNK cells (severe combined immunodeficient [SCID] or C57BL/6). Mated recipients were analyzed at midgestation. All grafts established uNK cells. Grafts from IFN-gamma(-/)-mice did not reverse host vascular or decidual pathology. Grafts from all other donors promoted modification of decidual arteries and decidual cellularity. Grafts from IFN-gammaRalpha(-/)- or Stat-1(-/)-mice overproduced uNK cells, all of which were immature. Grafts from IFN-gamma(-/)-, SCID, or C57BL/6 mice produced normal, mature uNK cells. Administration of murine recombinant IFN-gamma to pregnant RAG-2(-/)-gamma(c)(-/)-mice initiated decidual vessel modification and promoted decidual cellularity in the absence of uNK cells. These in vivo findings strongly suggest that uNK cell-derived IFN-gamma modifies the expression of genes in the uterine vasculature and stroma, which initiates vessel instability and facilitates pregnancy-induced remodeling of decidual arteries."xsd:string |
| http://purl.uniprot.org/citations/10899912 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.192.2.259"xsd:string |
| http://purl.uniprot.org/citations/10899912 | http://purl.uniprot.org/core/author | "Croy B.A."xsd:string |
| http://purl.uniprot.org/citations/10899912 | http://purl.uniprot.org/core/author | "Di Santo J.P."xsd:string |
| http://purl.uniprot.org/citations/10899912 | http://purl.uniprot.org/core/author | "Ashkar A.A."xsd:string |
| http://purl.uniprot.org/citations/10899912 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10899912 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/10899912 | http://purl.uniprot.org/core/pages | "259-270"xsd:string |
| http://purl.uniprot.org/citations/10899912 | http://purl.uniprot.org/core/title | "Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy."xsd:string |
| http://purl.uniprot.org/citations/10899912 | http://purl.uniprot.org/core/volume | "192"xsd:string |
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