| http://purl.uniprot.org/citations/10899917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10899917 | http://www.w3.org/2000/01/rdf-schema#comment | "This report shows that cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a key role in T cell-mediated dominant immunologic self-tolerance. In vivo blockade of CTLA-4 for a limited period in normal mice leads to spontaneous development of chronic organ-specific autoimmune diseases, which are immunopathologically similar to human counterparts. In normal naive mice, CTLA-4 is constitutively expressed on CD25(+)CD4(+) T cells, which constitute 5-10% of peripheral CD4(+) T cells. When the CD25(+)CD4(+) T cells are stimulated via the T cell receptor in vitro, they potently suppress antigen-specific and polyclonal activation and proliferation of other T cells, including CTLA-4-deficient T cells, and blockade of CTLA-4 abrogates the suppression. CD28-deficient CD25(+)CD4(+) T cells can also suppress normal T cells, indicating that CD28 is dispensable for activation of the regulatory T cells. Thus, the CD25(+)CD4(+) regulatory T cell population engaged in dominant self-tolerance may require CTLA-4 but not CD28 as a costimulatory molecule for its functional activation. Furthermore, interference with this role of CTLA-4 suffices to elicit autoimmune disease in otherwise normal animals, presumably through affecting CD25(+)CD4(+) T cell-mediated control of self-reactive T cells. This unique function of CTLA-4 could be exploited to potentiate T cell-mediated immunoregulation, and thereby to induce immunologic tolerance or to control autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.192.2.303"xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/author | "Yamazaki S."xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/author | "Sakaguchi N."xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/author | "Tagami T."xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/author | "Sakaguchi S."xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/author | "Shimizu J."xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/author | "Uede T."xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/pages | "303-310"xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/title | "Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4."xsd:string |
| http://purl.uniprot.org/citations/10899917 | http://purl.uniprot.org/core/volume | "192"xsd:string |
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