| http://purl.uniprot.org/citations/10903499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10903499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10903499 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Bungarotoxin, the main presynaptic neurotoxin purified from the venom of Bungarus multicinctus, consists of two dissimilar polypeptide chains, the A chain and the B chain, cross-linked by an interchain disulfide bond. In this study, A and B chain genes isolated from the liver of B. multicinctus encoded the A and B chain precursors, respectively. Analyses of the coding regions of the A and B chain genes revealed that both consist of three exons and two introns. The sequences of all exon/intron junctions agree with the GT/AG rule. However, sequence alignment and phylogenetic analysis did not support that the evolution of A and B chain genes are closely related. Comparative analysis of A chain genes with Viperinae and Crotalinae phospholipase A2 genes indicated that genetic divergence of the A chain and phospholipase A2s was in accordance with their family. Moreover, evolutionary divergence of the intron and exon regions of the A chain, as observed for phospholipase A2 genes, was not consistent. Noticeably, the transcription of A and B chain genes may be regulated under different transcription factors as revealed by analyses of their promoter sequences. In terms of the finding that A and B chains are encoded separately by different genes, this strongly supports the view that the intact beta-bungarotoxin molecules should be derived from the pairing of A and B chains after their mRNAs are translated."xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1432-1327.2000.01518.x"xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1432-1327.2000.01518.x"xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/author | "Chang L.-S."xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/author | "Chang L.-S."xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/author | "Wu P.-F."xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/author | "Wu P.-F."xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/pages | "4668-4675"xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/pages | "4668-4675"xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/title | "Genetic organization of A chain and B chain of beta-bungarotoxin from Taiwan banded krait (Bungarus multicinctus). A chain genes and B chain genes do not share a common origin."xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/title | "Genetic organization of A chain and B chain of beta-bungarotoxin from Taiwan banded krait (Bungarus multicinctus). A chain genes and B chain genes do not share a common origin."xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/volume | "267"xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://purl.uniprot.org/core/volume | "267"xsd:string |
| http://purl.uniprot.org/citations/10903499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10903499 |
| http://purl.uniprot.org/citations/10903499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10903499 |
| http://purl.uniprot.org/citations/10903499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10903499 |
| http://purl.uniprot.org/citations/10903499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10903499 |
| http://purl.uniprot.org/embl-cds/CAB62164.1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10903499 |
| http://purl.uniprot.org/uniprot/P00987 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10903499 |